- Review Article
- Other
- MicroRNAs as novel biomarkers for the diagnosis and treatment of pediatric diseases
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Hwal Rim Jeong, Il Tae Hwang
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Clin Exp Pediatr. 2024;67(3):119-125. Published online May 24, 2023
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MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post transcriptionally, and MiRNA expression levels vary with developmental stages. MiRNAs play an important role in several biological processes in children, including growth, neuro-development, inflammation, and tumor formation. Research on miRNAs may uncover the molecular mechanisms underlying various pediatric diseases, leading to the development of novel biomarkers that aid in the diagnosis, treatment, and prognosis of these diseases. |
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- Guideline
- Endocrinology
- 2017 Clinical practice guidelines for dyslipidemia of Korean children and adolescents
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Jung Sub Lim, Eun Young Kim, Jae Hyun Kim, Jae-Ho Yoo, Kyung Hee Yi, Hyun Wook Chae, Jin-Ho Choi, Ji Young Kim, Il Tae Hwang; the Committee of Dyslipidemia of Korean Children and Adolescents on behalf of Korean Society of Pediatric Endocrinology (KSPE)
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Clin Exp Pediatr. 2020;63(12):454-462. Published online November 25, 2020
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Question: How are children and adolescents with dyslipidemia treated and managed in Korea?
Finding: 2017 guidelines recommend to measure nonfasting non-HDL-C as a screening test and introduce new diet methods: Cardiovascular Health Integrated Lifestyle Diet (CHILD)-1, CHILD-2-low-density lipoprotein cholesterol, and CHILD-2-triglyceride. Statin is the only drug approved in children older than 10 years.
Meaning: New clinical practice guidelines for treating and managing dyslipidemia of Korean children and adolescents are provided. |
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- Original Article
- Developmental and Behavioral Medicine
- Behavioral and intelligence outcome in 8- to 16-year-old born small for gestational age
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Kyung Hee Yi, Yoon Young Yi, Il Tae Hwang
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Clin Exp Pediatr. 2016;59(10):414-420. Published online October 17, 2016
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Purpose We investigated behavioral problems, attention problems, and cognitive function in children and adolescents born small for gestational age (SGA). MethodsForty-six SGA children born at term and 46 appropriate for gestational age (AGA) children born at term were compared. Psychiatric symptoms were examined with reference to the Korean-Child Behavior Checklist, Korean-Youth Self Report, and Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS). Cognitive... |
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- Review Article
- Efficacy and safety of growth hormone treatment for children born small for gestational age
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Il Tae Hwang
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Clin Exp Pediatr. 2014;57(9):379-383. Published online September 30, 2014
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Recombinant growth hormone (GH) is an effective treatment for short children who are born small for gestational age (SGA). Short children born SGA who fail to demonstrate catch-up growth by 2-4 years of age are candidates for GH treatment initiated to achieve catch-up growth to a normal height in early childhood, maintain a normal height gain throughout childhood, and achieve... |
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- Original Article
- Catch up growth in children born small for gestational age by corrected growth curve
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Myung Ki Jung, Ji Eun Song, Seung Yang, Il Tae Hwang, Hae Ran Lee
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Clin Exp Pediatr. 2009;52(9):984-990. Published online September 15, 2009
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Purpose:Being small for gestational age (SGA) is a risk factor of short stature in children. Genetic background such as mid-parental height (MPH) is known to influence growth of children born SGA. We studied the relationship between growth of children born SGA and MPH and studied the effects of insulin-like growth factor (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3)... |
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- Review Article
- The present condition of Korean children born small for gestational age
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Il Tae Hwang
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Clin Exp Pediatr. 2009;52(2):137-141. Published online February 15, 2009
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Depending on the definition used, between 3% and 10% of live neonates are small for gestational age (SGA). The definition of SGA requires the following: (1) accurate knowledge of gestational age; (2) accurate measurements at birth of weight, length, and head circumference; (3) a cutoff, which has been variably set at the 10th percentile, 3rd percentile, or at less than... |
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- Original Article
- The relationship between adiponectin, leptin, insulin, insulin-like growth factor and IGF binding protein-3 in cord blood and neonatal anthropometric parameters
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Hai Jung Cho, Ji Young Kim, Me Jin Kim, Il Tae Hwang, Hae Ran Lee
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Clin Exp Pediatr. 2008;51(7):722-728. Published online July 15, 2008
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Purpose : This study was designed to examine the effects of adiponectin, leptin, insulin, insulin-like growth factor (IGF)-I and IGF binding protein (BP)-3 levels in cord blood on weight, length, and adiposity at birth in healthy term infants. In addition, we evaluated the mechanism to change the hormone levels in appropriate for gestational age (AGA) during the first month.
Methods :... |
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- The usefulness of skin test in evaluation of immunity to varicella
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Ji-Young Kim, Hye Jeen Lee, Me Jin Kim, Young Ho Kim, Ji A Jung, Seung Yang, Il Tae Hwang, Hae Ran Lee
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Clin Exp Pediatr. 2008;51(4):377-382. Published online April 15, 2008
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Purpose : The aim of this study is to assess the usefulness of skin test by an inactivated, 1/50 diluted solution of attenuated varicella vaccine in evaluating the immune status to varicella.
Methods : Total 41 subjects (22 males, 19 females, aged 1-32 years) were enrolled from July to August, 2005. Past medical history including varicella infection, varicella vaccination were investigated... |
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- Review Article
- Evaluation of function and disorders of the adrenal gland in neonates
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Il Tae Hwang
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Clin Exp Pediatr. 2007;50(3):236-240. Published online March 15, 2007
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Majority of sick full term newborns have adequate adrenal cortical function in response to stress. Acutely ill neonates with a basal cortisol level less than 15 g/dL (414 nmol/L) suggest adrenal insufficiency and require function testing of adrenal function. In premature infant, immaturity of hypothalamic-pituitary adrenal axis (HPA axis), may limit the ability to increase cortisol production in response... |
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- Original Article
- The Separate and Combined Effects of Insulin, Dexamethasone and
Growth Hormone on the OB Gene Expression and Leptin Secretion
from Cultured Human Visceral Adipose Tissue
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Il Tae Hwang, Kyung Hee Kim, Jin Soon Hwang, Choong Ho Shin, Sei Won Yang
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Clin Exp Pediatr. 2003;46(8):795-802. Published online August 15, 2003
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Purpose : We investigated the hormonal control of OB gene expression and leptin secretion in cultured human visceral adipose tissue.
Methods : Visceral adipose tissues were cultured for up to 48 hrs in modified Eagle's medium with varying concentration of hormones : Control(no hormone), bovine insulin(100 nM), Dexamethasone(DEX, 100 nM), growth hormone(GH, 40 ng/mL), insulin+DEX(100 nM each), insulin+DEX+GH(100 nM insulin... |
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- A Study of the Relationship between Childhood Obesity and Beverage Intake
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Ji Hyun Oh, In Keun Kwak, Seung Yang, Il Tae Hwang, Ji Ah Jung, Hae Ran Lee
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Clin Exp Pediatr. 2003;46(11):1061-1066. Published online November 15, 2003
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Purpose : The rising prevalence of childhood obesity may be due to an energy imbalance between food intake and energy expenditure. Recently, consumption of beverages in children has increased. The aim of this study is to provide useful information for the prevention and the control of childhood obesity by assessment of variable beverage consumption.
Methods : Fight hundred seventy seven children(M... |
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- Evaluation of Health Status and Growth and Developmental
Outcome of Intrauterine Growth-Retarded Infants
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Il Tae Hwang, Eun Ae Park, Ho Seong Kim, Gyoung Hee Kim
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Clin Exp Pediatr. 2001;44(6):635-641. Published online June 15, 2001
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Purpose : Although many children born with intrauterine growth retardation demonstrate significant catch-up growth in early childhood, substantial weight and height deficits remain in others. In addition, children with IUGR may demonstrate developmental deficits. The aims of this study are to evaluate the health status, growth and deveolpmental outcome of intrauterine growth retarded infants.
Methods : Sixty five intrauterine growth retarded... |
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- Risk Factors for Cardiovascular Disease in Obese Children
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Su Jin Cho, Se Jin Park, Il Tae Hwang, Young Mi Hong
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Clin Exp Pediatr. 2001;44(5):493-500. Published online May 15, 2001
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Purpose : Obesity is known to be associated with complications such as hypertension, dyslipidemia, and insulin resistance. The importance of insulin resistance and hyperinsulinemia have been emphasized in obesity. Homocysteine is an emerging important risk factor for cardiovascular disease in adult, but there are less reports about homocysteine in children. Several risk factors such as blood pressure, lipid profiles, serum... |
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- Case Report
- A Case of Intestinal Abnormal Rotation by Mesenteric Lymphangioma
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Eui Seok Park, Il Tae Hwang, Ghee Young Jung, Du Bong Lee, Hyo Seon Choi, Mi Kyung Jee
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Clin Exp Pediatr. 1997;40(9):1309-1313. Published online September 15, 1997
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Mesenteric lymphangioma was first recognized when an autopsy case was recorded
in 1507 by Benevieni. It has been known clinically rare disease and probably a congenital developmental abnormality due to failure of drainage of peripheral primary lymphatic spaces. We experienced a case of abnormal rotation in intestine by mesenteric lymphangioma in a 8 years old male who showed vomiting and abdominal... |
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- A Case of Spontaneouse Hemothorax Associated with a Posterior Mediastinal Endodermal Sinus Tumor in a Female Patient
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Eui Seok Park, Il Tae Hwang, Ghee Young Jung, Du Bong Lee, Young Sook Han, Hyo Seon Choi, Mi Kyeong Ji
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Clin Exp Pediatr. 1997;40(10):1465-1469. Published online October 15, 1997
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Primary endodermal sinus tumor(yolk sac tumor) of the mediastinum is rare. Most patients are
young and male, and the great majority of tumors are found in the anterior mediastinum, and
spontaneous hemothorax is a rare presentation of intrathoracic tumors.
We report a case of spontaneous hemothorax associated with a posterior mediastinal endoderml
sinus tumor occuring in a female patient. Brief review and related literatures... |
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